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dipyridamole will increase the stage or result of riociguat by lowering metabolism. Keep away from or Use Alternate Drug. Coadministration of riociguat (substrate of CYP isoenzymes 1A1, 2C8, 3A, 2J2) with robust CYP inhibitors may demand a decreased First dose of 0.five mg PO TID; watch for indications of hypotension and decrease dose if needed